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The Spectrum of Lissencephaly:Report of Ten Patients Analyzed by Magnetic Resonance Imaging Ann Neurol 30:139-146, Barkovich,A.J.,et al, 1991 See this aricle in Pubmed Article Abstract Clinical data and magnetic resonance imagining scans from 10 patients with lissencephaly were reviewed.Although 6 of the 10 patients were less than 1 year old at the time of their most recent examination,those who were old enough for developmental assessment were,with a single exception,severely developmentally delayed.All patients had anatomical features compatible with impaired neuronal migration but normal myelination and,consequently, adequate glial migration.The severity of the lissencephaly did not seem to correlate with the severity of the clinical manifestations.One patient showed less delayed development than anticipated,perhaps because the most severely involved region of the brain was the prefrontal area.

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(click to filter results - removes previous filter) colpocephaly corpus callosum developmental retardation electroencephalogram electroencephalogram,abnormalities of hypotonia lissencephaly malformation,CNS,congenital MRI MRI,abnormal neuronal migration disorder seizure

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